2i, or Not 2i: The Soliloquy of Nanog-Negative Mouse Embryonic Stem Cells
نویسندگان
چکیده
منابع مشابه
Stat3 phosphorylation is required for embryonic stem cells ground state maintenance in 2i culture media
Embryonic stem cells (ES cells) can be maintained its undifferentiated state with feeder cells or LIF, which can activate Jak/Stat3 pathway. Recently, it has been reported a new culture condition comprising serum-free medium with ERK and GSK3β inhibitors (2i) could drive ES cells into a state of pluripotency more like inner cell mass (ICM) in mouse blastocysts called ground state. However, alth...
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ژورنال
عنوان ژورنال: Stem Cell Reports
سال: 2018
ISSN: 2213-6711
DOI: 10.1016/j.stemcr.2018.06.017